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CAS No.: 50370-12-2

头孢羟氨苄 Catalog No. CSN10561

Synonyms: BL-S 578;Cephadroxil;Duricef

Cefadroxil is the first-generation Cephalosporin antibiotic, which exerts bactericidal activity by interfering with the later stages of bacterial cell wall synthesis through inactivation of one or more penicillin-binding proteins and inhibiting cross-linking of the peptidoglycan structure.

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技术信息

生物活性

描述Cefadroxil is a drug that has bactericidal activity and broad spectrum of action^[3]. Cefadroxil is an oral cephalosporin which is similar to cephalexin and cephradine in structure and spectrum of antibacterial activity, but has different pharmacokinetic properties. Not only does cefadroxil exhibit a longer serum half-life, and thus a prolonged duration of activity, but it is virtually unaffected by simultaneous food intake. The Peff (cm/s) (The effective permeability) of cefadroxil in wild-type mice was 0.49 × 10(-4) in duodenum, 0.80 × 10(-4) in jejunum, 0.88 × 10(-4) in ileum and 0.064 × 10(-4) in colon. Jejunal uptake of cefadroxil was saturable (Km = 2-4 mM) and significantly attenuated by the sodium-proton exchange inhibitor 5-(N,N-dimethyl)amiloride^[4]. Compared to the rats treated with free CDX (Cefadroxil), the CDX-CSNP1 (Cefadroxil loaded chitosan nanoparticles) treated group revealed a remarkable accelerated wound healing process and bacterial clearance which was further confirmed by the histopathological examination of skin biopsies^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00332163	Metastatic Colorectal Cancer ... more >> Skin Rash Skin Toxicities Colon Cancer Colorectal Cancer Collapse <<	Phase 2	Completed	-	-
NCT00405158	Mastitis	Not Applicable	Completed	-	Sweden ... more >> Dept Obstetrics & Gynecology, Helsingborg Hospital Helsingborg, Skane, Sweden, 25187 Collapse <<
NCT02814916	Methicillin-Resistant Staphylo... more >>coccus Aureus Bacterial Infections Staphylococcal Skin Infections Collapse <<	Phase 3	Recruiting	January 25, 2019	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7519 mL
- 13.7594 mL
- 27.5188 mL
- 5 mM
- 0.5504 mL
- 2.7519 mL
- 5.5038 mL
- 10 mM
- 0.2752 mL
- 1.3759 mL
- 2.7519 mL

技术信息

CAS号

50370-12-2

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H17N3O5S

运输

蓝冰

分子量

363.39

别名

BL-S 578;Cephadroxil;Duricef;Monohydrate;S-578;Ultracef;Cephadroxyl;头孢羟氨苄

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00332163	Metastatic Colorectal Cancer ... more >> Skin Rash Skin Toxicities Colon Cancer Colorectal Cancer Collapse <<	Phase 2	Completed	-	-
NCT00405158	Mastitis	Not Applicable	Completed	-	Sweden ... more >> Dept Obstetrics & Gynecology, Helsingborg Hospital Helsingborg, Skane, Sweden, 25187 Collapse <<
NCT02814916	Methicillin-Resistant Staphylo... more >>coccus Aureus Bacterial Infections Staphylococcal Skin Infections Collapse <<	Phase 3	Recruiting	January 25, 2019	-
NCT00332163	-	-	Completed	-	-
NCT02297815	-	-	Completed	-	United States, Pennsylvania ... more >> The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Collapse <<
NCT02297815	-	-	Completed	-	-
NCT01244698	Bacterial Infection ... more >> Anti-infective Agents Breast Implantation Collapse <<	Phase 4	Completed	-	United States, New York ... more >> Stony Brook University Medical Center Stony Brook, New York, United States, 11792 Collapse <<
NCT01845363	Obesity	Phase 4	Completed	-	Brazil ... more >> Universidade Federal de Pernambuco - Hospital das Clínicas Recife, Pernambuco, Brazil, 50670901 Collapse <<
NCT00835081	Healthy	Phase 1	Completed	-	United States, Texas ... more >> Bioassay Laboratory, Inc. Houston, Texas, United States, 77099 Canada, Ontario Biovail Contract Research Toronto, Ontario, Canada, M1L 4R6 Collapse <<
NCT00834275	-	-	Completed	-	-
NCT00834275	Healthy	Phase 1	Completed	-	United States, Texas ... more >> Bioassay Laboratory, Inc. Houston, Texas, United States, 77099 Canada, Ontario Biovail Contract Research Toronto, Ontario, Canada, M1L 4R6 Collapse <<
NCT02749981	-	-	Completed	-	-
NCT02446496	Infections, Urinary Tract	Phase 4	Completed	-	Egypt ... more >> GSK Investigational Site Cairo, Egypt Collapse <<
NCT02446496	-	-	Completed	-	-
NCT00835081	-	-	Completed	-	-
NCT02479867	Healthy	Phase 1	Completed	-	Egypt ... more >> Genuine Research Center GRC Cairo, Egypt Collapse <<
NCT02140281	Healthy Volunteers	Phase 1	Completed	-	United States, Kansas ... more >> Research Site Overland Park, Kansas, United States Collapse <<

头孢羟氨苄 Catalog No. CSN10561

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